SUMO-1 modification activates the transcriptional response of p53
نویسندگان
چکیده
منابع مشابه
SUMO-1 modification of MEF2A regulates its transcriptional activity
Myocyte enhancer factor 2 (MEF2) transcription factors are crucial regulators controlling muscle-specific and growth factor-inducible genes. Numerous studies have reported that the activity of these transcription factors is tightly modulated by posttranslational modifications such as activation by specific phosphorylation as well as repression by class II histone deacetylases (HDACs). We hypoth...
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Mdm2 is an E3 ubiquitin ligase for the p53 tumor suppressor protein. We demonstrate that Mdm2 is conjugated with SUMO-1 (sumoylated) at Lys-446, which is located within the RING finger domain and plays a critical role in Mdm2 self-ubiquitination. Whereas mutant Mdm2(K446R) is stabilized, it elicits increased degradation of p53 and concomitant inhibition of p53-mediated apoptosis. In vitro sumoy...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 1999
ISSN: 0261-4189,1460-2075
DOI: 10.1093/emboj/18.22.6455